BRAF variants causing MAPK activation

(A) Different BRAF constructs used for RCAS-mediated gene delivery. Truncated variants containing the kinase domain corresponded to exons 9–18 of the human BRAF gene. The V600E mutation is indicated. (B) Phase-contrast microscopy demonstrated altered cell morphology and focal growth of cells transduced with BRAF VE kin compared with control and other BRAF constructs. Scale bars: 100 μm.

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